MATERIAL SAFETY DATA SHEET

L-TYROSINE

1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY INFORMATION

PRODUCT NAME: L-TYROSINE
SYNONYMS: beta-(p-Hydroxyphenyl) Alanine

2. COMPOSITION/INFORMATION ON INGREDIENTS

3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW: May cause skin irritation and/or dermatitis
PRINCIPLE ROUTES OF EXPOSURE: Skin
INHALATION: May cause irritation of respiratory tract
INGESTION: May be harmful if swallowed.
SKIN CONTACT: May cause allergic skin reaction
EYE CONTACT: Avoid contact with eyes
STATEMENTS OF HAZARD MAY CAUSE ALLERGIC SKIN REACTION.
STATEMENT OF SPILL OR LEAK - ANSI LABEL Eliminate all ignition sources. Absorb and/or contain spill with inert materials (e.g., sand, vermiculite). Then place in appropriate container. For large spills, use water spray to disperse vapors, flush spill area. Prevent runoff from entering waterways or sewers.

4.   FIRST AID MEASURES

GENERAL ADVICE: In the case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
INHALATION: Move to fresh air. Call a physician immediately.
SKIN CONTACT: Rinse immediately with plenty of water and seek medical advice
INGESTION: Do not induce vomiting without medical advice.
EYE CONTACT: In the case of contact with eyes, rinse immediately with plenty of water and seek
medical advice.

PROTECTION OF FIRST-AIDERS: No information available
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: None known

5.   FIRE FIGHTING MEASURES

SUITABLE EXTINGUISHING MEDIA: Use dry chemical, CO2, water spray or "alcohol" foam
SPECIFIC HAZARDS: Burning produces irritant fumes.
UNUSUAL HAZARDS: None known
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS: As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear
SPECIFIC METHODS: Water mist may be used to cool closed containers.
FLASH POINT: Not determined
AUTOIGNITION TEMPERATURE: Not determined
NFPA RATING:
NFPA Health: 1
NFPA Flammability: 1
NFPA Reactivity: 0

6.   ACCIDENTAL RELEASE MEASURES

PERSONAL PRECAUTIONS: Use personal protective equipment.
ENVIRONMENTAL PRECAUTIONS: Prevent product from entering drains.
METHODS FOR CLEANING UP: Sweep up and shovel into suitable containers for disposal.

7.   HANDLING AND

STORAGE: ROOM TEMPERATURE
HANDLING: Use only in area provided with appropriate exhaust ventilation.
SAFE HANDLING ADVICE: Wear personal protective equipment.
INCOMPATIBLE PRODUCTS: Oxidising and spontaneously flammable products

8.   EXPOSURE CONTROLS / PERSONAL PROTECTION

ENGINEERING MEASURES: Ensure adequate ventilation.
PERSONAL PROTECTIVE EQUIPMENT
RESPIRATORY PROTECTION: Breathing apparatus only if aerosol or dust is formed.
HAND PROTECTION: Pvc or other plastic material gloves
SKIN AND BODY PROTECTION: Usual safety precautions while handling the product will provide adequate protection against this potential effect.
EYE PROTECTION: Safety glasses with side-shields
HYGIENE MEASURES: Handle in accordance with good industrial hygiene and safety practice.

9.   PHYSICAL AND CHEMICAL PROPERTIES

APPEARANCE AND ODOR WHITE
PHYSICAL STATE: Powder
FORMULA: C9H11 NO3
MOLECULAR WEIGHT: 181.2
MELTING POINT/RANGE: 342-344°C
BOILING POINT/RANGE: No Data available at this time.
DENSITY: 1.4 g/ml
VAPOR PRESSURE: No data available
EVAPORATION RATE: No data available
VAPOR DENSITY: No data available

SOLUBILITY (IN WATER): Slightly soluble
FLASH POINT: Not determined
AUTOIGNITION TEMPERATURE: Not determined

10.  STABILITY AND REACTIVITY

STABILITY: Stable under recommended storage conditions.
POLYMERIZATION: None under normal processing.
HAZARDOUS DECOMPOSITION PRODUCTS: Nitrogen oxides (NOx)/ammonia/CNMaterials
TO AVOID: Strong oxidising agents
CONDITIONS TO AVOID: Exposure to air or moisture over prolonged periods.

11.  TOXICOLOGICAL INFORMATION

PRODUCT INFORMATION
ACUTE TOXICITY
COMPONENTS RTECS NUMBER: Selected LD50s and LC50s
L-TYROSINE YP2275600 Not Determined
CHRONIC TOXICITY: Chronic exposure may cause nausea and vomiting, higher exposure causes unconsciousness.
LOCAL EFFECTS: Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting.
SPECIFIC EFFECTS: May include moderate to severe erythema (redness) and moderate edema (raised skin), nausea, vomiting, headache.
PRIMARY IRRITATION: No data is available on the product itself.
CARCINOGENIC EFFECTS: No data is available on the product itself.
MUTAGENIC EFFECTS: No data is available on the product itself.
REPRODUCTIVE TOXICITY: No data is available on the product itself.

12.  ECOLOGICAL INFORMATION

MOBILITY: No data available
BIOACCUMULATION: No data available
ECOTOXICITY EFFECTS: No data available
AQUATIC TOXICITY: May cause long-term adverse effects in the aquatic environment.
Components U.S. DOT - Appendix B - Marine Pollutan
U.S. DOT - Appendix B - Severe Marine Pollutants
United Kingdom - The Red List:
L-TYROSINE Not Listed Not Listed Not Listed
Components Germany VCI (WGK) World Health Organization
(WHO) - Drinking Water Ecotoxicity - Fish Species Data
L-TYROSINE Not Listed Not Listed Not Listed
Components Ecotoxicity – Freshwater Algae Data Ecotoxicity - Microtox Data Ecotoxicity - Water Flea
Data L-TYROSINE Not Listed Not Listed Not Listed
Components EPA - ATSDR Priority List EPA - HPV Challenge
Program Chemical List California - Priority Toxic
Pollutants L-TYROSINE Not Listed Not Listed Not Listed
Components California - Priority Toxic Pollutants California - Priority Toxic Pollutants
L-TYROSINE Not Listed Not Listed

13.  DISPOSAL CONSIDERATIONS

WASTE FROM RESIDUES / UNUSED PRODUCTS: Waste disposal must be in accordance with appropriate Federal, State, and local regulations. This product, if unaltered by use, may be disposed of by treatment at a permitted facility or as advised by your local hazardous waste regulatory authority. Residue from fires extinguished with this material may be hazardous.
CONTAMINATED PACKAGING: Do not re-use empty containers

14.  TRANSPORT INFORMATION

UN/Id No: Not regulated
DOT:
PROPER SHIPPING NAME: Not Regulated
Components U.S. DOT - Appendix A Table 1 - Reportable Quantities
L-TYROSINE Not Listed
TDG (CANADA):
WHMIS HAZARD CLASS: Non-controlled
IMDG/IMO IMDG - Hazard Classifications Not Applicable
Components U.S. DOT - Appendix B - Marine Pollutan U.S. DOT - Appendix B - Severe
Marine Pollutants
L-TYROSINE Not Listed Not Listed
IMO-labels:

15.  REGULATORY INFORMATION

International Inventories
Present
EU EINECS List - 200-460-4; C9H11 NO3
Components
L-TYROSINE
INVENTORY - JAPAN: 9-1596
CANADA DSL INVENTORY LIST - Present
KOREAN KECL:KE-01396
PHILIPPINES PICCS: Present
AUSTRALIA (AICS): Present
CATALOG NUMBER: 103183
Inventory - United States TSCA - Sect. 8(b)
PRODUCT NAME: L-TYROSINE Page 4 of 5
INVENTORY - CHINA: Present
U.S. regulations:
Components California Proposition 65
Massachusetts Right to
KNOW LIST:

NEW JERSEY RIGHT TO KNOW LIST:
PENNSYLVANIA RIGHT TO KNOW LIST:
L-TYROSINE Not Listed Not Listed Not Listed Not Listed
COMPONENTS FLORIDA SUBSTANCE LIST: Rhode Island Right to KNOW LIST:
Illinois-Toxic Air
Contaminants
Connecticut - Hazardous Air
Pollutants
L-TYROSINE Not Listed Not Listed Not Listed Not Listed
STATE NOTIFICATION: The above information is your notice as to the Right-to-Know listings of the stated product(s). Individual states will list chemicals for a variety of reasons including, but not limited to, the compounds toxicity; carcinogenic, tumorigenic and/or reproductive hazards; and the compounds environmental impact if accidentally released.